However,Ĭartilage OA is an inflammatory condition where Is superimposed with cartilage fragments. It is generally an acute phase inflammation that Usually, OA is an aging-relatedĭisease and not considered to be a sort of inflammatoryĭisease. Of the extracellular matrix proteins of cartilage,įor example, type II collagen, proteoglycans and A complex system ofĬytokines and proteolytic enzymes cause degradation Synovial aggravation, subchondral bone sclerosis,Īnd osteophyte development. Osteoarthritis (OA) is an incessant joint diseaseĭescribed by dynamic cartilage degeneration, Monosodium iodoacetate, hyperalgesia, spontaneous motility
Osteoarthritis, morin, interleukin-1β, chondrocytes, nitric oxide, matrix metalloproteinases, Collectively, these findings demonstrated that morin could be a potential chondroprotective that could be used in the treatment of osteoarthritis Keywords Besides, morin also significantly reduced the level of proinflammatory cytokines in the serum of osteoarthritic mice. Furthermore, in monosodium iodoacetate-induced osteoarthritis in mice, it was found that morin at 25 and 50 mg/kg, significantly reduced the heat hyperalgesia and increased the spontaneous motility in mice on days 7, 14, and 21. Moreover, morin also significantly decreased the levels of matrix metalloproteinases. Results obtained showed that morin effectively attenuated in vitro the production of inflammatory mediators, nitric oxide and prostaglandin E2. The present investigation was aimed to evaluate the antiosteoarthritic effect of morin in isolated primary rat chondrocytes in the presence of interleukin-1β. DOI: 10.36468/pharmaceutical-sciences.644 Abstract
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